There has been a rise in the problem of Non-Communicable Diseases (NCDs) worldwide. Non- Communicable Diseases NCDs are chronic conditions and as such takes a toll on the family and the community. In Ghana, NCDs are attributed to supernatural causes, hence this study was done to assess people’s knowledge and perception on NCDs, factors that influence their health seeking behaviours and how their religious beliefs affect the treatment of NCDs. The descriptive survey design through the quantitative approach was used in the study. Through stratified and random sampling procedures, a sample of 386 respondents were selected from Ayawaso District of Ghana. A questionnaire designed (in relation to literature) was used to gather data for the study. The gathered data was analyzed based on the research questions, using descriptive statistics (frequency and percentage) and pearson product moment correlation. The findings of the study indicated that majority of the respondents have knowledge on NCDs, they first seek for the causes and treatment of the NCDs and there is a weak positive significant correlation between religion and seeking early intervention of NCD. Recommendations were made to contribute to optimizing the management of NCDs in the Ayawaso district of Ghana.