The employment of advanced technology in sustaining South African humanitarian organizations and business logistics firms has been a crucial concern for many years. The aim of this study is to examine the propensity of senior executives to use, diffuse, and adopt Humanitarian Logistics Digital Business Ecosystem (HLDBE) as another future sustainable tool. A PLS-SEM multivariate analysis was conducted using technology innovation theories to understand their perceived interest. The findings indicated that donor/top-level management support (D_TLMS), normative pressure (NP), perceived compatibility (PC), and perceived safety and security concerns (PSSC) served as essential factors that influenced decision-makers decision to use, diffuse, and adopt HLDBE with their noted concerns indicated. An IPMA analysis was also used in assisting executives on important factors to improve. Implications, limitations, and further research directions are therein proposed.