Over the years, the issue of waste generation and management have been a major issue of concern, stemming a number of countries around the world, thus, developing countries. The ultimate aim of this study was to investigate into the effects of indiscriminate disposal of waste in and around the Keta Lagoon in the Volta region of Ghana. The study highlighted quite a number of respondents, who had lived in the area for quite a lengthy period and had observed the changes with regards to rapid deteriorating conditions of sanitation in the area as well as the aesthetic nature of the lagoon per the value it served decades ago and now. It is for these reasons why the study sought to look at what had contributed to the diminishing state of the Keta Lagoon, which is a designated Ramsar site (Ramsar Convention, 1971), hence, its importance to Ghana as a nation. The absence of waste management services, ignorance and lack of law enforcement units were identified as key factors, playing a fundamental role to indiscriminate dumping of refuse in and around the Keta Lagoon. Based on key findings, recommendations on sensitising or educating the inhabitants as well as the general public on sanitation in basic schools would create some level of awareness. Strengthening and equipping the Municipal Assembly in the area by the government would help ensure frequent monitoring and regulate waste management in the area.