A fifty-year study of land cover changes in Ghana’s south-eastern region is conducted to identify major shifts and new avenues for justifiable growth and development. This study sought to assess the historical changes (1970–2020) associated with the region’s land use systems, topography and land surface temperature. It further investigated the relationship between some given remotely sensed variables using autocorrelation and geoinformatics. Findings proved socio-political and economic factors have caused massive shift in land cover and prevailing climatic conditions through increasing settlements and migration, the extensiveness of agriculture, poverty, unregulated and unreported logging of trees, small-scale mining intensification, and weak governance systems. We discovered that the natural vegetation had dramatically reduced (? 52.01%), whilst built-up (+?406.05%), farmlands/shrubs (+?86.47%), and waterbodies (+?47.35) were faced with a drastic increase. Class contribution rates show built environment massively influenced land modification, compared to other surveyed classes. In light of the major influences observed, it can be concluded that dynamics in land-use systems caused a substantial drift in local temperature. Temperature and built-up index correlated strongly (R2?=0.959, ?p