Enterprises are constantly experiencing higher levels of supply chain disruptions in their operations due to the expansion of industries’ business networks. It becomes very necessary for enterprises to continually assess risks in their business operations. To mitigate the adverse consequences of such potential supply chain risks on the perfor-mance of enterprises, it becomes imperative for Ghanaian enterprises to implement adequate supply chain risk management strategies. The purpose of this paper is to outline potential risks in the supply chain network of Ghanaian enterprises and investigate the impact of these potential risks and supply chain risk management (SCRM) strategies on enterprise performance. Data for the study was collected from 210 enterprises in Ghana and analyzed by modeling the constructs of supply chain risks, supply chain risk management (SCRM) strategies and enterprise performance and also measuring the complex relationships among the constructs using a structural approach. The structural model result shows that, enterprises with distinct organizational structures dedicated to supply chain risk management with the purpose of mitigating supply chain risks tend to perform better than their competitors. The results also indicated a negative association between supply chain risks and the performance of Ghanaian enterprises. This research provides direction for managers to adopt and develop adequate enterprise supply chain risk register and supply chain risk management (SCRM) strategies to mitigate the consequences of supply chain risks in their planned business operations