The study examined the impact of infant mortality on the population in West Africa from 2004 to 2015 with panel data methodologies. The study used fully modified ordinary least square method to analysis the data to make its statistical inference. The results report negative and statistical significance impact of infant mortality and population growth in West Africa. Further, the study found out that human development contributes a lot to the mitigation of infant mortality hence, improvement in governments’ effectiveness and regulation quality will translate into good quality of life, which then increases population growth. The study recommends that governments’ should formulate proactive policies and ensure their implementation to help mitigate infant mortality which in the long run affects population growth negatively