The study examines the effect of government expenditure on secondary education on secondary school enrollment and economic growth in Ghana in time series study from 1971 to 2018. The study employed time series methodologies to make its statistical analysis. However, fully modified ordinary least square, Wald test and granger causality tests were performed to ascertain the long run, short run and direction of causality among the variables. The study found that government expenditure on education has positive effect on economic growth and secondary school enrollment in both the long and short run but has insignificant effect in the short run on secondary school enrollment. Furthermore, government expenditure on secondary education has insignificant effect on both economic growth and secondary school enrollment in the long and short run but negative effect on economic growth in the short run. Moreover, the study found bidirectional causality relationship between secondary school enrollment and pupil-teacher ratio in secondary education. The study recommends that government should focus expending on the entire education sector due its tendency to increase economic growth and secondary school enrollment but not solely focusing on secondary education.