The purpose of the study was to explore the school-related factors that affect girls’ access to education at the basic school level in the Tarkwa-Nsuaem Municipality of the Western Region of Ghana. The study used the descriptive survey design with quantitative approach. Survey questionnaires were used to gather data from 451 Form one and two girls who were selected through purposive sampling. The gathered data was analyzed by using frequencies and percentages. The findings of the study revealed that school factors such as lack of teaching and learning materials, distance to school from where pupils stay and lack of basic needs in school such as books and pens affect girls’ access to basic education in the municipality. Conclusion and recommendation: It was concluded that the factors that affect girls’ access to education at the basic level do not operate in isolation. Therefore finding solutions to these factors, should be done in their totality rather than providing solutions to each of the factors separately. Recommendations were made based on the need for the provision of adequate teachings and learning materials, and basic needs such as books and pens by stakeholders of education, and provision of transportation to pupils who stay at distant places form their schools.