Cervical cancer has become prevalent in this 21st century and women living with it must adopt coping strategies to remediate such conditions. The study sought to ascertain the relationship between religious coping and self-esteem of women living with cervical cancer in Ghana. The descriptive survey design through the quantitative approach was used in the study. Through stratified and simple random sampling procedures, a sample of 113 respondents were selected from a population of 160 women living cervical cancer. Brief RCOPE and Rosenberg Self-Esteem Scale were used to collect data for the study. The gathered data was analysed using descriptive and inferential statistics such as means, standard deviations, Pearson product Moment Correlation and MANOVA. The findings of the study revealed that women with cervical cancer has normal levels of self-esteem (Overall mean of 3.51 out of 4.0). In terms of religious coping, most of the respondents (76.6%) used positive religious coping. The result of the study also found a statistically significant but moderate relationship between religious coping and self-esteem (r = .53, p < .001) with 28% of the variance in self-esteem being explained by positive religious coping. The findings further revealed a statistically significant difference in the negative religious coping practices with respect to respondents’ religious background [F (2, 108) = 4.33, p = .015, with partial eta squared = .074]. However, for positive religious copying, the study revealed no statistically significant difference with respect to respondents’ religious background [F (2, 108) = 1.21, p = .304, partial eta squared = .022]. Recommendations were made on the need to place interest in religious coping and high self-esteem by stakeholders.